AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

Fragile X syndrome, the most common form of inherited intellectual disability, is caused by a lack of FMRP, which is the product of the Fmr1 gene. FMRP is an RNA-binding protein and a component of RNA-granules found in the dendrites of neurons. At the synapse, FMRP is involved in regulation of trans...

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Bibliographic Details
Main Authors: Josien Levenga, Shigemi Hayashi, Femke M.S. de Vrij, Sebastiaan K. Koekkoek, Herma C. van der Linde, Ingeborg Nieuwenhuizen, Cheng Song, Ronald A.M. Buijsen, Andreea S. Pop, Baltazar GomezMancilla, David L. Nelson, Rob Willemsen, Fabrizio Gasparini, Ben A. Oostra
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
AFQ056
PPI
Spine morphology
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100043X

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http://www.sciencedirect.com/science/article/pii/S096999611100043X

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