Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion

Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion

Contractility of the human heart increases as its beating rate is elevated, so-called positive force-frequency relationship; however, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been reported to exert a negative force-frequency relationship. We tested the hypothesis t...

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Bibliographic Details
Main Authors: Hiroko Izumi-Nakaseko, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ayano Satsuka, Ai Goto, Yoshio Nunoi, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Yasunari Kanda, Atsuhiko T. Naito, Atsushi Sugiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
contraction velocity-frequency relationship
frequency-dependent enhancement of relaxation
human induced pluripotent stem cell-derived cardiomyocytes
field potential
motion vector
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.542562/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.542562/full

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