Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and amino acids for protein synthesis. Critical enzymes...

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Bibliographic Details
Main Authors: M. Ryan Smith, Praveen K. Vayalil, Fen Zhou, Gloria A. Benavides, Reena R. Beggs, Hafez Golzarian, Bhavitavya Nijampatnam, Patsy G. Oliver, Robin A.J. Smith, Michael P. Murphy, Sadanandan E. Velu, Aimee Landar
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Bioenergetics
IBTP
Redox signaling
Seahorse extracellular flux analysis
Tricarboxylic acid cycle
Krebs cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300027

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http://www.sciencedirect.com/science/article/pii/S2213231716300027

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