Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells

Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells

Abstract Background Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly expressed in tumors. It has been hypothesized that Survivin facilitates carcinogenesis by inhibition of apoptosis resulting in improved survival of tumorigenic progeny. Additionally, Survivin plays...

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Bibliographic Details
Main Authors: Marina Conde, Susanne Michen, Ralf Wiedemuth, Barbara Klink, Evelin Schröck, Gabriele Schackert, Achim Temme
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Cancer
Subjects:
Glioma
BIRC5/Survivin
DNA damage
p53
Chromosomal instability
Online Access:http://link.springer.com/article/10.1186/s12885-017-3932-y

Internet

http://link.springer.com/article/10.1186/s12885-017-3932-y

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