DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Tet-transactivators are used for direct regulation of gene expression, RNA interference and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death in antigen-activated lymphocytes in vivo, putting into question the use of, and in vivo data gener...

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Bibliographic Details
Main Authors: Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J. Herold, Andreas Strasser, Andreas Villunger
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01022-4

Internet

https://doi.org/10.1038/s41467-017-01022-4

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