The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mouse model

The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mouse model

Alport syndrome (AS) is a hereditary glomerular nephritis caused by mutation in one of the type IV collagen genes α3/α4/α5 that encode the heterotrimer COL4A3/4/5. Failure to form a heterotrimer due to mutation leads to the dysfunction of the glomerular basement membrane, and end-stage renal disease...

Full description

Bibliographic Details
Main Authors: Yuya Sannomiya, Shota Kaseda, Misato Kamura, Hiroshi Yamamoto, Hiroyuki Yamada, Masataka Inamoto, Jun Kuwazuru, Saki Niino, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Renal Failure
Subjects:
alport syndrome
discoidin domain receptor 2 (ddr2)
type iv collagen
proteinuria
inflammatory cytokines
fibrosis
Online Access:http://dx.doi.org/10.1080/0886022X.2021.1896548

Internet

http://dx.doi.org/10.1080/0886022X.2021.1896548

Similar Items