Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome. Owing to the complexity of the KIR locus, with extensive gene copy number varia...

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Bibliographic Details
Main Authors: Ines Wagner, Daniel Schefzyk, Jens Pruschke, Gerhard Schöfl, Bianca Schöne, Nicole Gruber, Kathrin Lang, Jan Hofmann, Christine Gnahm, Bianca Heyn, Wesley M. Marin, Ravi Dandekar, Jill A. Hollenbach, Johannes Schetelig, Julia Pingel, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Vinzenz Lange
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
next generation sequencing
NGS
KIR genotyping
KIR
killer cell immunoglobulin-like receptors
allele-level resolution
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02843/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02843/full

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