Sex‐dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: Randomized multicenter EORTC 05011 trial

Sex‐dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: Randomized multicenter EORTC 05011 trial

Abstract The least toxic time (LTT) of irinotecan varied by up to 8 hours according to sex and genetic background in mice. The translational relevance was investigated within a randomized trial dataset, where no LTT stood out significantly in the whole population. 130 male and 63 female eligible pat...

Full description

Bibliographic Details
Main Authors: Pasquale F. Innominato, Annabelle Ballesta, Qi Huang, Christian Focan, Philippe Chollet, Abdoulaye Karaboué, Sylvie Giacchetti, Mohamed Bouchahda, René Adam, Carlo Garufi, Francis A. Lévi
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Cancer Medicine
Subjects:
chronotherapy
circadian
colorectal cancer
gender
irinotecan
toxicity
Online Access:https://doi.org/10.1002/cam4.3056

Internet

https://doi.org/10.1002/cam4.3056

Similar Items