Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells

Abstract Background The G1 checkpoint is a critical regulator of genomic stability in untransformed cells, preventing cell cycle progression after DNA damage. DNA double-strand breaks (DSBs) recruit and activate ATM, a kinase which in turn activates the CHK2 kinase to establish G1 arrest. While the...

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Bibliographic Details
Main Authors: Iraia García-Santisteban, Alba Llopis, Lenno Krenning, Jon Vallejo-Rodríguez, Bram van den Broek, Ana M. Zubiaga, René H. Medema
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Biology
Subjects:
CHK2
ATM
G1 checkpoint
DNA damage
Online Access:https://doi.org/10.1186/s12915-021-00965-x

Internet

https://doi.org/10.1186/s12915-021-00965-x

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