DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

Abstract Background Genetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson’s disease (PD). Since cell reprogramming and the generation of induced pluripotent stem cells (iPSCs) are themselves associated with...

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Bibliographic Details
Main Authors: Laura de Boni, Gilles Gasparoni, Carolin Haubenreich, Sascha Tierling, Ina Schmitt, Michael Peitz, Philipp Koch, Jörn Walter, Ullrich Wüllner, Oliver Brüstle
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Isogenic stem cells
iPS cell-derived neurons
Online Access:http://link.springer.com/article/10.1186/s13148-018-0440-0

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http://link.springer.com/article/10.1186/s13148-018-0440-0

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