Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic skin disorder of unknown etiology that manifests as recurrent, painful lesions. Cutaneous dysbiosis and unresolved inflammation are hallmarks of active HS, but their origin and interplay remain unclear. Our metabolomic profiling of HS skin revealed an abnor...

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Bibliographic Details
Main Authors: Laure Guenin-Macé, Jean-David Morel, Jean-Marc Doisne, Angèle Schiavo, Lysiane Boulet, Véronique Mayau, Pedro Goncalves, Sabine Duchatelet, Alain Hovnanian, Vincent Bondet, Darragh Duffy, Marie-Noëlle Ungeheuer, Maïa Delage, Aude Nassif, James P. Di Santo, Caroline Demangel
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-10-01
Series:JCI Insight
Subjects:
Dermatology
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.140598

Internet

https://doi.org/10.1172/jci.insight.140598

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