Chemotherapy‐Enriched THBS2‐Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

Chemotherapy‐Enriched THBS2‐Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

Abstract The physical microenvironment is a critical mediator of tumor behavior. However, detailed biological and mechanistic insight is lacking. The present study reveals the role of chemotherapy‐enriched CD133+ liver cancer stem cells (CSCs) with THBS2 deficiency. This subpopulation of cells contr...

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Bibliographic Details
Main Authors: Kai‐Yu Ng, Queenie T. Shea, Tin‐Lok Wong, Steve T. Luk, Man Tong, Chung‐Mau Lo, Kwan Man, Jing‐Ping Yun, Xin‐Yuan Guan, Terence K. Lee, Yong‐Ping Zheng, Stephanie Ma
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Advanced Science
Subjects:
cancer stemness
CD133
hepatocellular carcinomas
histone modifications
matrix stiffness
mechanoepigenetics
Online Access:https://doi.org/10.1002/advs.202002483

Internet

https://doi.org/10.1002/advs.202002483

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