An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.

In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced miRNA are known to inhibit specific viruses, it is not known whether host...

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Bibliographic Details
Main Authors: Kevin A Robertson, Wei Yuan Hsieh, Thorsten Forster, Mathieu Blanc, Hongjin Lu, Peter J Crick, Eylan Yutuc, Steven Watterson, Kimberly Martin, Samantha J Griffiths, Anton J Enright, Mami Yamamoto, Madapura M Pradeepa, Kimberly A Lennox, Mark A Behlke, Simon Talbot, Jürgen Haas, Lars Dölken, William J Griffiths, Yuqin Wang, Ana Angulo, Peter Ghazal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002364

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https://doi.org/10.1371/journal.pbio.1002364

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