Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase

Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase

Selective cyclo-oxygenase-2 (COX-2) inhibitors are nonsteroidal antiinflammatory drugs used in the management of inflammatory diseases. We demonstrate here that inhibition of the COX-2 enzyme impairs adipocyte differentiation. The inhibition of adipogenesis occurs in the early clonal expansion phase...

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Bibliographic Details
Main Authors: Lluis Fajas, Stéphanie Miard, Michael R. Briggs, Johan Auwerx
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Journal of Lipid Research
Subjects:
peroxisome proliferator activated receptor γ
cell cycle
insulin resistance
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337275

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http://www.sciencedirect.com/science/article/pii/S0022227520337275

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