Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo

Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo

About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for n...

Full description

Bibliographic Details
Main Authors: Jeannine Lacroix, Zoltán Kis, Rafael Josupeit, Franziska Schlund, Alexandra Stroh-Dege, Monika Frank-Stöhr, Barbara Leuchs, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Viruses
Subjects:
Ewing sarcoma
protoparvovirus H-1 (H-1PV)
oncolytic virus
lytic infection
apoptosis
Online Access:http://www.mdpi.com/1999-4915/10/6/302

Internet

http://www.mdpi.com/1999-4915/10/6/302

Similar Items