Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis

Hematopoietic stem cells arise from mesoderm-derived hemogenic endothelium (HE) during embryogenesis in a process termed endothelial-hematopoietic transition (EHT). To better understand the gene networks that control this process, we investigated the role of the transcription factor HEB (TCF12) by d...

Full description

Bibliographic Details
Main Authors: Yang Li, Patrick M. Brauer, Jastaranpreet Singh, Sintia Xhiku, Kogulan Yoganathan, Juan Carlos Zúñiga-Pflücker, Michele K. Anderson
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
human embryonic stem cell
genome editing
transcriptional regulation
HEB
mesoderm
hemogenic endothelium
hematopoiesis
Runx1
Notch1
T cell development
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303211

Internet

http://www.sciencedirect.com/science/article/pii/S2213671117303211

Similar Items