Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73<sup>-</sup> Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73<sup>-</sup> Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes

The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and...

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Bibliographic Details
Main Authors: Parimah Ahmadi, Philip Hartjen, Matin Kohsar, Silke Kummer, Stefan Schmiedel, Jan-Hendrik Bockmann, Anahita Fathi, Samuel Huber, Friedrich Haag, Julian Schulze zur Wiesch
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
COVID-19
purinergic signaling
CD73
CD39
cytotoxic lymphocytes
granzyme B
Online Access:https://www.mdpi.com/2073-4409/9/8/1750

Internet

https://www.mdpi.com/2073-4409/9/8/1750

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