Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type

Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type

Alport syndrome is a hereditary progressive chronic kidney disease caused by mutations in type IV collagen genes COL4A3/4/5. X-linked Alport syndrome (XLAS) is caused by mutations in the COL4A5 gene and is the most common form of Alport syndrome. A strong correlation between the type of COL4A5 mutat...

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Bibliographic Details
Main Authors: Cong Wang, Shenghui Liang, Shijia Xing, Ke Xu, Huijie Xiao, Haiyue Deng, Xiaoyuan Wang, Liangyi Chen, Jie Ding, Fang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
COL4A5 mutation
Alport syndrome
induced pluripotent stem cell
fibroblast
endoplasmic reticulum stress
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00036/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00036/full

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