The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a 68Ga-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a 68Ga-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-receptor mediated radionuclide imaging and therapy. We have previously shown that an antagonist analog of bombesin RM26 conjugated to 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOT...

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Bibliographic Details
Main Authors: Zohreh Varasteh, Ulrika Rosenström, Irina Velikyan, Bogdan Mitran, Mohamed Altai, Hadis Honarvar, Maria Rosestedt, Gunnar Lindeberg, Jens Sörensen, Mats Larhed, Vladimir Tolmachev, Anna Orlova
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
bombesin analog
PEG
GRPR
antagonist
molecular imaging
breast cancer
prostate cancer
BT-474
PC-3 cells
Online Access:http://www.mdpi.com/1420-3049/19/7/10455

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http://www.mdpi.com/1420-3049/19/7/10455

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