HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

Abstract Background The worldwide pandemic caused by the SARS-CoV-2 virus is characterized by significant and unpredictable heterogeneity in symptoms that remains poorly understood. Methods Transcriptome and single cell transcriptome of COVID19 lung were integrated with deeplearning analysis of MHC...

Full description

Bibliographic Details
Main Authors: Christophe Desterke, Ali G. Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Translational Medicine
Subjects:
COVID-19
Macrophage
Immunoproteasome
HLA
Peptidome
Antigen presentation
Online Access:https://doi.org/10.1186/s12967-021-02965-5

Similar Items

Similar Items