MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

Abstract Background Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the antitumor mechanism of MASTL targeting in cancer cells is still unclear....

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Bibliographic Details
Main Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh, Jae-Sung Kim
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Cancer
Subjects:
MASTL
Mitotic catastrophe
Radiation
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12885-018-4600-6

Internet

http://link.springer.com/article/10.1186/s12885-018-4600-6

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