GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg

We conducted an experimental database analysis to determine the expression of 61 CD4+ Th subset regulators in human and murine tissues, cells, and in T-regulatory cells (Treg) in physiological and pathological conditions. We made the following significant findings: (1) adipose tissues of diabetic pa...

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Bibliographic Details
Main Authors: Keman Xu, William Y. Yang, Gayani Kanchana Nanayakkara, Ying Shao, Fan Yang, Wenhui Hu, Eric T. Choi, Hong Wang, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
CD4+ T helper subset differentiation
CD4+ FOXP3+ regulatory T cells
metabolic cardiovascular diseases
Th1-like Treg
APC-like Treg
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00045/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00045/full

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