Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer (CRC). However, no MACC1 inhibitors have been identified yet. Therefore, we aimed to target MACC1 exp...

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Bibliographic Details
Main Authors: Manisha Juneja, Dennis Kobelt, Wolfgang Walther, Cynthia Voss, Janice Smith, Edgar Specker, Martin Neuenschwander, Björn-Oliver Gohlke, Mathias Dahlmann, Silke Radetzki, Robert Preissner, Jens Peter von Kries, Peter Michael Schlag, Ulrike Stein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5453412?pdf=render

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http://europepmc.org/articles/PMC5453412?pdf=render

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