Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical tre...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14256 |