Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical tre...
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doaj-2cab827465544f808fc531ab3590aa8a2021-05-11T07:10:19ZengNature Publishing GroupNature Communications2041-17232017-02-018111310.1038/ncomms14256Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effectsMark Lucanic0W. Todd Plummer1Esteban Chen2Jailynn Harke3Anna C. Foulger4Brian Onken5Anna L. Coleman-Hulbert6Kathleen J. Dumas7Suzhen Guo8Erik Johnson9Dipa Bhaumik10Jian Xue11Anna B. Crist12Michael P. Presley13Girish Harinath14Christine A. Sedore15Manish Chamoli16Shaunak Kamat17Michelle K. Chen18Suzanne Angeli19Christina Chang20John H. Willis21Daniel Edgar22Mary Anne Royal23Elizabeth A. Chao24Shobhna Patel25Theo Garrett26Carolina Ibanez-Ventoso27June Hope28Jason L Kish29Max Guo30Gordon J. Lithgow31Monica Driscoll32Patrick C. Phillips33The Buck Institute for Research on AgingThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityThe Buck Institute for Research on AgingThe Buck Institute for Research on AgingDivision of Aging Biology, National Institute on AgingThe Buck Institute for Research on AgingDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers UniversityInstitute of Ecology and Evolution, University of OregonIrreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.https://doi.org/10.1038/ncomms14256 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mark Lucanic W. Todd Plummer Esteban Chen Jailynn Harke Anna C. Foulger Brian Onken Anna L. Coleman-Hulbert Kathleen J. Dumas Suzhen Guo Erik Johnson Dipa Bhaumik Jian Xue Anna B. Crist Michael P. Presley Girish Harinath Christine A. Sedore Manish Chamoli Shaunak Kamat Michelle K. Chen Suzanne Angeli Christina Chang John H. Willis Daniel Edgar Mary Anne Royal Elizabeth A. Chao Shobhna Patel Theo Garrett Carolina Ibanez-Ventoso June Hope Jason L Kish Max Guo Gordon J. Lithgow Monica Driscoll Patrick C. Phillips |
spellingShingle |
Mark Lucanic W. Todd Plummer Esteban Chen Jailynn Harke Anna C. Foulger Brian Onken Anna L. Coleman-Hulbert Kathleen J. Dumas Suzhen Guo Erik Johnson Dipa Bhaumik Jian Xue Anna B. Crist Michael P. Presley Girish Harinath Christine A. Sedore Manish Chamoli Shaunak Kamat Michelle K. Chen Suzanne Angeli Christina Chang John H. Willis Daniel Edgar Mary Anne Royal Elizabeth A. Chao Shobhna Patel Theo Garrett Carolina Ibanez-Ventoso June Hope Jason L Kish Max Guo Gordon J. Lithgow Monica Driscoll Patrick C. Phillips Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects Nature Communications |
author_facet |
Mark Lucanic W. Todd Plummer Esteban Chen Jailynn Harke Anna C. Foulger Brian Onken Anna L. Coleman-Hulbert Kathleen J. Dumas Suzhen Guo Erik Johnson Dipa Bhaumik Jian Xue Anna B. Crist Michael P. Presley Girish Harinath Christine A. Sedore Manish Chamoli Shaunak Kamat Michelle K. Chen Suzanne Angeli Christina Chang John H. Willis Daniel Edgar Mary Anne Royal Elizabeth A. Chao Shobhna Patel Theo Garrett Carolina Ibanez-Ventoso June Hope Jason L Kish Max Guo Gordon J. Lithgow Monica Driscoll Patrick C. Phillips |
author_sort |
Mark Lucanic |
title |
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects |
title_short |
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects |
title_full |
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects |
title_fullStr |
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects |
title_full_unstemmed |
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects |
title_sort |
impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-02-01 |
description |
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment. |
url |
https://doi.org/10.1038/ncomms14256 |
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