Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway

Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway

High intraocular pressure (IOP)-induced retinal ischemia leads to acute glaucoma, which is one of the leading causes of irreversible visual-field loss, characterized by loss of retinal ganglion cells (RGCs) and axonal injury in optic nerves (ONs). Oxidative stress and the inflammatory response play...

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Bibliographic Details
Main Authors: Longxiang Sheng, Bingzheng Lu, Hui Chen, Yun Du, Chen Chen, Wei Cai, Yang Yang, Xuyan Tian, Zhaofeng Huang, Wei Chi, Suizhen Lin, Guangmei Yan, Wei Yin
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Marine Drugs
Subjects:
acute glaucoma
5α-androst-3β, 5α, 6β-triol (TRIOL)
NF-E2-related factor 2 (Nrf2)
ischemic-reperfusion (I/R) injury
Online Access:https://www.mdpi.com/1660-3397/17/5/267

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https://www.mdpi.com/1660-3397/17/5/267

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