PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S]

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S]

Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein, we show that the LDLR cell surface levels dra...

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Bibliographic Details
Main Authors: Anna Roubtsova, Ann Chamberland, Jadwiga Marcinkiewicz, Rachid Essalmani, Ali Fazel, John J. Bergeron, Nabil G. Seidah, Annik Prat
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Lipid Research
Subjects:
lipoproteins/receptors
ldl/metabolism
liver
cholesterol
estrogen
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354821

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520354821

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