Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of hyperpolarizing synaptic transmission, but here we identif...

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Bibliographic Details
Main Authors: Yvonne E. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
KCC2
depolarizing GABA
autism
cognition
social behavior
memory
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00173/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00173/full

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