Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Bone morphogenetic protein (BMP) receptors are single pass transmembrane serine/threonine kinases that form tetrameric complexes comprised of two type I and two type II BMP receptors. Here the authors characterize a structure of an active type I/type II kinase tetramer providing insight into molecul...

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Bibliographic Details
Main Authors: Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25248-5

Internet

https://doi.org/10.1038/s41467-021-25248-5

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