Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer

Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer

Abstract Background Therapeutic resistance is the main cause of death in metastatic colorectal cancer. To investigate genomic plasticity, most specifically of metastatic lesions, associated with response to first‐line systemic therapy, we collected longitudinal liver metastatic samples and character...

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Main Authors: Karen Gambaro, Maud Marques, Suzan McNamara, Mathilde Couetoux du Tertre, Zuanel Diaz, Cyrla Hoffert, Archana Srivastava, Steven Hébert, Benoit Samson, Bernard Lespérance, Yoo‐Joung Ko, Richard Dalfen, Eve St‐Hilaire, Lucas Sideris, Felix Couture, Ronald Burkes, Mohammed Harb, Errol Camlioglu, Adrian Gologan, Vincent Pelsser, André Constantin, Celia M.T. Greenwood, Sabine Tejpar, Petr Kavan, Claudia L. Kleinman, Gerald Batist
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Clinical and Translational Medicine
Subjects:
colorectal cancer
copy number aberrations
metastasis
treatment response
Online Access:https://doi.org/10.1002/ctm2.401

Internet

https://doi.org/10.1002/ctm2.401

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