Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line.

Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line.

Galectin-9 (Gal-9), a lectin having a β-galactoside-binding domain, can induce apoptosis of Th1 cells by binding to TIM-3. In addition, Gal-9 inhibits IgE/Ag-mediated degranulation of mast cell/basophilic cell lines by binding to IgE, thus blocking IgE/Ag complex formation. However, the role of Gal-...

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Main Authors: Reiji Kojima, Tatsukuni Ohno, Motoyasu Iikura, Toshiro Niki, Mitsuomi Hirashima, Keichi Iwaya, Hitoshi Tsuda, Shigeaki Nonoyama, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465902/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465902/?tool=EBI

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