Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppress...

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Bibliographic Details
Main Authors: Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Michael Platten, Ines Heiland, Christiane A. Opitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
liver
hypoxia
tryptophan
TDO2
regulation
AHR activity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.590532/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.590532/full

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