ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

The cytosolic antiviral innate immune sensor RIG-I distinguishes 5′ tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain. Recently discovered mutations in ATPase motifs...

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Bibliographic Details
Main Authors: Charlotte Lässig, Sarah Matheisl, Konstantin MJ Sparrer, Carina C de Oliveira Mann, Manuela Moldt, Jenish R Patel, Marion Goldeck, Gunther Hartmann, Adolfo García-Sastre, Veit Hornung, Karl-Klaus Conzelmann, Roland Beckmann, Karl-Peter Hopfner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
RIG-I
RLR
innate immune system
ATPase domain
autoimmune response / disease
singleton-merten syndrome
Online Access:https://elifesciences.org/articles/10859

Internet

https://elifesciences.org/articles/10859

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