Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

Most bacteria use an indirect pathway to generate aminoacylated glutamine and/or asparagine tRNAs. Clinical isolates of Mycobacterium tuberculosis with increased rates of error in gene translation (mistranslation) involving the indirect tRNA-aminoacylation pathway have increased tolerance to the fir...

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Bibliographic Details
Main Authors: Swarnava Chaudhuri, Liping Li, Matthew Zimmerman, Yuemeng Chen, Yu-Xiang Chen, Melody N Toosky, Michelle Gardner, Miaomiao Pan, Yang-Yang Li, Qingwen Kawaji, Jun-Hao Zhu, Hong-Wei Su, Amanda J Martinot, Eric J Rubin, Veronique Anne Dartois, Babak Javid
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
mistranslation
persister
antibiotic tolerance
kasugamycin
Online Access:https://elifesciences.org/articles/36782

Internet

https://elifesciences.org/articles/36782

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