Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.

Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.

Mutations in SOD1 cause hereditary variants of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous, with toxicity deriving also from glia. In particular, microglia contribute to disease progression. Methylene blue (MB) inhibits th...

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Main Authors: Payam Dibaj, Jana Zschüntzsch, Heinz Steffens, Jörg Scheffel, Bettina Göricke, Jochen H Weishaupt, Karim Le Meur, Frank Kirchhoff, Uwe-Karsten Hanisch, Eike D Schomburg, Clemens Neusch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3428282?pdf=render

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http://europepmc.org/articles/PMC3428282?pdf=render

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