Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby induces HIV-1 transcription. An interaction with host Ser/Thr protein phosphatase-1 (PP1) is critical for this function of Tat. PP1 binds to a Tat sequence, Q(35)VCF(38), which resembles the PP1-bindin...

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Bibliographic Details
Main Authors: Tatiana Ammosova, Maxim Platonov, Venkat R K Yedavalli, Yuri Obukhov, Victor R Gordeuk, Kuan-Teh Jeang, Dmytro Kovalskyy, Sergei Nekhai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3387161?pdf=render

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http://europepmc.org/articles/PMC3387161?pdf=render

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