Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity

Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity

Abstract Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has physiological functions in the central nervous system, but also is invol...

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Bibliographic Details
Main Authors: Emil Gregersen, Cristine Betzer, Woojin S. Kim, Gergo Kovacs, Lasse Reimer, Glenda M. Halliday, Steffen Thiel, Poul Henning Jensen
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Neuroinflammation
Subjects:
α-Synuclein
Complement system
MSA
Neurodegeneration
SH-SY5Y
RaCI
Online Access:https://doi.org/10.1186/s12974-021-02225-9

Internet

https://doi.org/10.1186/s12974-021-02225-9

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