Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome

Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome

Summary: Haploinsufficiency of EHMT1, which encodes histone H3 lysine 9 (H3K9) methyltransferase G9a-like protein (GLP), causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability. Here, we examined whether postnatal supply of GLP can reverse the neurologic...

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Bibliographic Details
Main Authors: Ayumi Yamada, Takae Hirasawa, Kayako Nishimura, Chikako Shimura, Naomi Kogo, Kei Fukuda, Madoka Kato, Masaki Yokomori, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Yoichiro Iwakura, Itoshi Nikaido, Shigeyoshi Itohara, Yoichi Shinkai
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Pathophysiology
Behavioral neuroscience
Molecular neuroscience
Developmental neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221007094

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http://www.sciencedirect.com/science/article/pii/S2589004221007094

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