Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition

Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition

Induction of tumor-specific cytotoxic CD8+ T cells (CTLs) via immunization relies on the presentation of tumor-associated peptides in major histocompatibility complex (MHC) class I molecules by dendritic cells (DCs). To achieve presentation of exogenous peptides into MHC class I, cytosolic processin...

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Bibliographic Details
Main Authors: Dorian A. Stolk, Sophie K. Horrevorts, Sjoerd T.T. Schetters, Laura J.W. Kruijssen, Sanne Duinkerken, Eelco Keuning, Martino Ambrosini, Hakan Kalay, Rieneke van de Ven, Juan J. Garcia-Vallejo, Tanja D. de Gruijl, Sandra J. van Vliet, Yvette van Kooyk
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
mono-palmitoylation
palmitic acid
peptide modification
antigen
dendritic cell
anti-tumor
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000590

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http://www.sciencedirect.com/science/article/pii/S2372770521000590

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