PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.

PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.

Combination with other small molecule drugs represents a promising strategy to improve therapeutic efficacy of FLT3 inhibitors in the clinic. We demonstrated that combining ABT-869, a FLT3 inhibitor, with SAHA, a HDAC inhibitor, led to synergistic killing of the AML cells with FLT3 mutations and sup...

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Bibliographic Details
Main Authors: Jianbiao Zhou, Chonglei Bi, Wee-Joo Chng, Lip-Lee Cheong, Shaw-Cheng Liu, Sylvia Mahara, Kian-Ghee Tay, Qi Zeng, Jie Li, Ke Guo, Cheng Peow Bobby Tan, Hanry Yu, Daniel H Albert, Chien-Shing Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3093398?pdf=render

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http://europepmc.org/articles/PMC3093398?pdf=render

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