Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer

Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer

Abstract Background Intra-tumoral heterogeneity has been recently addressed in different types of cancer, including breast cancer. A concept describing the origin of intra-tumoral heterogeneity is the cancer stem-cell hypothesis, proposing the existence of cancer stem cells that can self-renew limit...

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Bibliographic Details
Main Authors: Pascale Kündig, Charlotte Giesen, Hartland Jackson, Bernd Bodenmiller, Bärbel Papassotirolopus, Sandra Nicole Freiberger, Catharine Aquino, Lennart Opitz, Zsuzsanna Varga
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Translational Medicine
Subjects:
Intratumoral heterogeneity
Breast cancer
Stem cells
Tumor progression
Tissue micro array
Online Access:http://link.springer.com/article/10.1186/s12967-018-1495-6

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http://link.springer.com/article/10.1186/s12967-018-1495-6

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