Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224

Since proprotein convertase subtilisin kexin 9 (PCSK9) discovery, a gene involved in LDL metabolism regulation and cardiovascular diseases (CVD), many therapeutic strategies have been introduced for direct targeting of PCSK9. The main goal of these strategies has been to reduce PCSK9 protein level e...

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Bibliographic Details
Main Authors: Parisa Naeli, Fatemeh Mirzadeh Azad, Mahshid Malakootian, Nabil G. Seidah, Seyed J. Mowla
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00189/full