Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality

Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality

Expression of Pitx2 on the left side of the embryo patterns left-right (LR) organs including the dorsal mesentery (DM), whose asymmetric cell behavior directs gut looping. Despite the importance of organ laterality, chromatin-level regulation of Pitx2 remains undefined. Here, we show that genes imme...

Full description

Bibliographic Details
Main Authors: Ian C. Welsh, Hojoong Kwak, Frances L. Chen, Melissa Werner, Lindsay S. Shopland, Charles G. Danko, John T. Lis, Min Zhang, James F. Martin, Natasza A. Kurpios
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009882

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715009882

Similar Items