Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material

Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material

The world-first success of lipid nanoparticle (LNP)-based siRNA therapeutics (ONPATTRO<sup>®</sup>) promises to accelerate developments in siRNA therapeutics/gene therapy using LNP-type drug delivery systems (DDS). In this study, we explore the optimal composition of an LNP containing a...

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Bibliographic Details
Main Authors: Hiroki Tanaka, Nae Takata, Yu Sakurai, Tokuyuki Yoshida, Takao Inoue, Shinya Tamagawa, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Masatoshi Maeki, Manabu Tokeshi, Hidetaka Akita
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
siRNA
antisense oligonucleotide
lipid nanoparticle
Online Access:https://www.mdpi.com/1999-4923/13/4/544

Internet

https://www.mdpi.com/1999-4923/13/4/544

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