An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

Abstract Introduction Genome-wide association studies (GWAS) have successfully identified multiple independent genetic loci that harbour variants associated with Alzheimer’s disease, but the exact causal genes and biological pathways are largely unknown. Methods To prioritise likely causal genes ass...

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Bibliographic Details
Main Authors: Zachary F. Gerring, Michelle K. Lupton, Daniel Edey, Eric R. Gamazon, Eske M. Derks
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Gene expression
Genome-wide association study
Genetics
Genetic epidemiology
Computational biology
Online Access:http://link.springer.com/article/10.1186/s13195-020-00611-8

Internet

http://link.springer.com/article/10.1186/s13195-020-00611-8

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