Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis.

Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis.

BACKGROUND: Fungal components have been shown very effective in generating Th17 responses. We investigated whether exposure to a minute amount of C. albicans in the arthritic joint altered the local cytokine environment, leading to enhanced Th17 expansion and resulting in a more destructive arthriti...

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Bibliographic Details
Main Authors: Renoud J Marijnissen, Marije I Koenders, Frank L van de Veerdonk, John Dulos, Mihai G Netea, Annemieke M H Boots, Leo A B Joosten, Wim B van den Berg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3373564?pdf=render

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http://europepmc.org/articles/PMC3373564?pdf=render

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