Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks

Metastasis is the major cause of cancer deaths and control of gene transcription has emerged as a critical contributing factor. RhoA- and RhoC-induced gene transcription via the actin-regulated transcriptional co-activator megakaryocytic leukemia (MKL) and serum response factor (SRF) drive metastasi...

Full description

Bibliographic Details
Main Authors: Chris R. Evelyn, Erika M. Lisabeth, Susan M. Wade, Andrew J. Haak, Craig N. Johnson, Elizabeth R. Lawlor, Richard R. Neubig
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Microarrays
Subjects:
metastasis
transcription
cell cycle
Rho
Online Access:http://www.mdpi.com/2076-3905/5/2/13

Internet

http://www.mdpi.com/2076-3905/5/2/13

Similar Items