Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Metabolic reprogramming is a molecular hallmark of cancer. Recently, we have reported the overexpression of glyoxalase 1 (encoded by <i>GLO1</i>), a glutathione-dependent enzyme involved in detoxification of the reactive glycolytic byproduct methylglyoxal, in human malignant melanoma cel...

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Bibliographic Details
Main Authors: Jana Jandova, Jessica Perer, Anh Hua, Jeremy A. Snell, Georg T. Wondrak
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
malignant melanoma
glyoxalase 1
epithelial–mesenchymal transition
matrix metalloproteinase 9
SCID mouse metastasis model
transwell invasion
Online Access:https://www.mdpi.com/2072-6694/12/6/1369

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https://www.mdpi.com/2072-6694/12/6/1369

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