Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

Summary: Upon infection, antigen-specific naive CD8 T cells are activated and differentiate into short-lived effector cells (SLECs) and memory precursor cells (MPECs). The underlying signaling pathways remain largely unresolved. We show that Rictor, the core component of mammalian target of rapamyci...

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Bibliographic Details
Main Authors: Lianjun Zhang, Benjamin O. Tschumi, Isabel C. Lopez-Mejia, Susanne G. Oberle, Marten Meyer, Guerric Samson, Markus A. Rüegg, Michael N. Hall, Lluis Fajas, Dietmar Zehn, Jean-Pierre Mach, Alena Donda, Pedro Romero
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471501551X

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http://www.sciencedirect.com/science/article/pii/S221112471501551X

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