Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to β-adrenergic overstimulation. After isopr...

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Bibliographic Details
Main Authors: Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kämmerer
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
PDE2
arrhythmia
CaMKII
heart failure
Online Access:https://www.mdpi.com/1422-0067/22/9/4816

Internet

https://www.mdpi.com/1422-0067/22/9/4816

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